Acute pyelonephritis (APN) is one of the most common serious bacterial infections in children and a significant cause of renal morbidity if not promptly diagnosed and adequately treated. In recent years, the concept of ambulatory (outpatient) management of selected pediatric patients with APN has gained increasing attention due to advances in diagnostic tools, antimicrobial therapy, and structured follow-up protocols. However, clear clinical criteria for safe outpatient treatment remain under discussion. The aim of this study was to evaluate the clinical characteristics, treatment strategies, and short-term outcomes of children with acute pyelonephritis managed in ambulatory settings. A retrospective and prospective observational analysis was conducted involving pediatric patients diagnosed with APN based on clinical presentation, laboratory findings, and imaging data. Key parameters included age distribution, severity of symptoms, laboratory markers of inflammation, antimicrobial regimens, duration of therapy, complications, and need for hospitalization. Results demonstrated that carefully selected children with mild to moderate APN, stable hemodynamic status, preserved oral intake, and reliable parental supervision can be effectively managed in outpatient settings. Early initiation of empiric antibiotic therapy followed by targeted treatment based on urine culture results was associated with favorable clinical outcomes and low complication rates. Hospital referral was required in cases of persistent fever, vomiting, systemic toxicity, or laboratory signs of severe inflammation. Ambulatory management of acute pyelonephritis in children appears to be a safe and effective strategy when strict clinical criteria and structured monitoring protocols are applied. This approach may reduce hospital burden while maintaining high standards of pediatric care.

Acute pyelonephritis, pediatric urinary tract infection, outpatient management

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