Thrombosis is a complex pathological process characterized by the formation of a blood clot within the vascular system, which is one of the most dangerous conditions for human health [1]. In explaining this process, the concept of Virchow's triad — endothelial damage, impaired blood flow (stasis), and hyperhomocoagulation — is accepted as the main pathophysiological mechanism [2]. In the last decade, molecular and clinical studies of each component of this triad have revealed many new aspects of the development of thrombosis [3]. For example, endothelial dysfunction occurs as a result of atherosclerosis, hypertension, chronic inflammation, and oxidative stress, which leads to the loss of anticoagulant properties of the vascular wall and creates conditions for thrombus formation [4]. Stasis of blood flow is observed in the venous system, especially in conditions such as heart failure, varicose veins, or prolonged immobilization, and it increases erythrocyte aggregation and platelet adhesion to the wall [5]. Hyperhemocoagulation can be associated with genetic mutations (e.g., F5 Leiden or Prothrombin G20210A) or develop secondarily as a result of pregnancy, cancer, or autoimmune diseases [6].

Studies from 2020–2025 have shown that these three factors are interconnected and synergistically increase the risk of thrombosis [7]. Also, using RNA-seq and proteomics technologies, the expression of endothelial inflammatory markers (e.g., ICAM-1, VCAM-1, IL-6) has been found to increase the susceptibility to thrombosis [8]. At the same time, thrombotic events associated with cardiovascular diseases, COVID-19 infection, and hormonal therapy are also explained on the basis of Virchow's triad [9].

This article analyzes the role of each component of Virchow's triad in the formation of thrombosis and their modern molecular mechanisms. The results of the study provide an important theoretical and practical basis for individualizing the prevention and treatment of thrombosis [10].

Virchow's triad, thrombosis, endothelial damage, blood flow stasis

MICROFLORA, Dilshodovich KH SHIELD OF INTESTINAL. "CHANGE EFFECT ON THE GLANDS." American Journal of Pediatric Medicine and Health Sciences (2993-2149) 1 (2023): 81-83.

Dilshodovich, Khalilov Hikmatulla, Kayimov Mirzohid Normurotovich, and Esanov Alisher Akromovich. "RELATIONSHIP BETWEEN THYROID DISEASE AND TYPE 2 DIABETES." (2023).

To’laganovna, Y. M. (2025). SKELET MUSKULLARNING FIZIOLOGIYASI VA ULARNING ISHLASH MEXANIZMI: AKTIN VA MIOZIN VA ENERGIYA ASOSLARI. AMERICAN JOURNAL OF SOCIAL SCIENCE, 3(4), 54-60.

Tolaganovna, Y. M., & Shavkatjon o’g’li, A. A. (2025). INSON ORGANIZMIDA YURAK QON-TOMIR KALSALLIKLARI, MIOKARD INFARKTINING KELIB CHIQISH SABABLARI VA ULARNING OLISH CHORA–TADBIRLARI. AMERICAN JOURNAL OF APPLIED MEDICAL SCIENCE, 3(4), 136-144.

Jоʻrаbеk, K. (2025). BUYRАK KАSАLLIKLАRGА ОLIB KELАDIGАN PАTАLОGIK HОLАTLАR VА ULАRNI ОLDINI ОLISH. AMERICAN JOURNAL OF APPLIED MEDICAL SCIENCE, 3(4), 129-135.

Azimova, S. B., and H. D. Khalikov. "Modern pathogenetic aspects of urolithiasis development." The American Journal of Medical Sciences and Pharmaceutical Research 7.04 (2025): 21-24.

Dilshod ogli, Xalilov Hikmatulla, and Qayimov Mirzohid Normurotovich. "THE ROLE OF ARTIFICIAL INTELLIGENCE AND ROBOTICS IN MEDICINE." Web of Medicine: Journal of Medicine, Practice and Nursing 3, no. 5 (2025): 201-207.

To’laganovna, Yusupova Moxira. "SKELET MUSKULLARNING FIZIOLOGIYASI VA ULARNING ISHLASH MEXANIZMI: AKTIN VA MIOZIN VA ENERGIYA ASOSLARI." AMERICAN JOURNAL OF SOCIAL SCIENCE 3.4 (2025): 54-60.

Ogli, Xalilov Hikmatulla Dilshod, Namiddinov Abror Anasbek Ogli, Sayfullayeva Durdona Dilshod Qizi, and Hikmatova Gulasal Farhodjon Qizi. "TELEMEDITSINANING PROFILAKTIK DAVOLANISHDA AHAMIYATI." Eurasian Journal of Academic Research 4, no. 4-2 (2024): 66-70.

Dilshod ogli, Xalilov Hikmatulla, Amirqulov Navro'zbek To'rayevich, and Shukurov Umidjon Majid o’g’li. "GIPOTIREOIDIZMNI EKSPERIMENTAL MODELLASHTIRISH." AMERICAN JOURNAL OF APPLIED MEDICAL SCIENCE 3.2 (2025): 207-209.

Xalilov, H. D., Namiddinov, A. A., Berdiyev, O. V., & Ortiqov, O. S. (2024). GIPERTIROIDIZM VA YURAK ETISHMOVCHILIGI. Research and Publications, 1(1), 60-63.

Berdiyev, O. V., M. Quysinboyeva, and A. Sattorova. "Telemeditsina Orqali Qalqonsimon Bez Kasalliklarini Boshqarish." Open Academia: Journal of Scholarly Research 2.6 (2024): 69-74.

Karabayev, Sanjar. "SOG'LIQNI SAQLASHDA TELETIBBIYOT IMKONIYATLARI, XUSUSIYATLARI VA TO'SIQLARI." Yeвразийский журнал медицинских и естественных наук 3.2 Part 2 (2023): 41-46.

Шадманова, Н.К. and Халилов, Х.Д., 2023. НАУЧНО-ПРАКТИЧЕСКИЙ ИНТЕРЕС ИЗУЧЕНИЯ ВЕГЕТАТИВНОЙ РЕГУЛЯЦИИ ДИЗАДАПТИВНЫХ РЕАКЦИЙ СЕРДЕЧНО-СОСУДИСТОЙ СИСТЕМЫ. Евразийский журнал академических исследований, 3(8), pp.126-134.

Normurotovich, Qayimov Mirzohid, and Ganjiyeva Munisa Komil Qizi. "GIPOTIROIDIZM VA YURAK ETISHMOVCHILIGI." Eurasian Journal of Academic Research 4, no. 5-3 (2024): 14-19.

Normurotovich, Q. M. "Dilshod ogli XH RODOPSIN G OQSILLARI FILOGENETIK TAHLIL." Journal of new century innovations 43, no. 2 (2023): 178-183.

Maxira, Yusupova, Xalilov Hikmatulla Dilshod ogli, and Berdiyev Otabek Vahob ogli. "FIZIOLOGIYA FANI RIVOJLANISHI TIBBIYOTDAGI AHAMYATI. FIZIOLOGIYADA TADQIQOT USULLARI." PEDAGOG 7.12 (2024): 111-116.

MICROFLORA DK. CHANGE EFFECT ON THE GLANDS. American Journal of Pediatric Medicine and Health Sciences (2993-2149). 2023;1:81-3.

Dilshodovich, Khalilov Hikmatulla. "SHIELD OF INTESTINAL MICROFLORA CHANGE EFFECT ON THE GLANDS." American Journal of Pediatric Medicine and Health Sciences (29932149) 1 (2023): 81-83.

Dilshodovich, K.H., Normurotovich, K.M. and Akromovich, E.A., 2023. RELATIONSHIP BETWEEN THYROID DISEASE AND TYPE 2 DIABETES.

Dilshod ogly, Khalilov Hikmatulla, Shatursunova Madina Abdujamilovna, and Shukurov Umidjon Majid ogly. "THE IMPORTANCE OF ARTIFICIAL INTELLIGENCE IN THE DETECTION OF KIDNEY DISEASES MODERN APPROACHES AND PROSPECTS." Western European Journal of Modern Experiments and Scientific Methods 3.04 (2025): 9-13.

Ikrom, T., 2025. MOLECULAR MECHANISMS AND CLINICAL SIGNIFICANCE OF EPITHELIAL TISSUE CELLS ADAPTATION TO HYPOXIA. Western European Journal of Modern Experiments and Scientific Methods, 3(05), pp.15-22.

Ikrom, Tilyabov. "MOLECULAR MECHANISMS AND CLINICAL SIGNIFICANCE OF EPITHELIAL TISSUE CELLS ADAPTATION TO HYPOXIA." Western European Journal of Modern Experiments and Scientific Methods 3.05 (2025): 15-22.

Abdujamilovna, S.M. and Dilshod ogli, X.H., 2025. QAND MIQDORINING SUYAKLANISHGA TA’SIRI. Continuing education: international experience, innovation, and transformation, 1(10), pp.137-141.

Абдухаликова, Нигора Фахриддиновна, and Хикматулла Халилов. "РОЛЬ ЦИТОХРОМА И В МЕХАНИЗМАХ КЛЕТОЧНОГО ДЫХАНИЯ И ГИПОКСИИ." Advanced methods of ensuring the quality of education: problems and solutions 2.11 (2025): 62-68.

Абдухаликова, Нигора Фахриддиновна, and Хикматулла Халилов. "РОЛЬ СУКЦИНАТДЕГИДРОГЕНАЗЫ В МЕХАНИЗМАХ ГИПОКСИИ." Advanced methods of ensuring the quality of education: problems and solutions 2.11 (2025): 55-61.

Faxriddinovna, Abduxalikova Nigora, Xalilov Hikmatulla Dilshod ogli, and Jabborov Botir Baxodir ogli. "EOZINOFIL FAGASITOZ QILISH MEXANIZMLARI." Advanced methods of ensuring the quality of education: problems and solutions 2.11 (2025): 44-54.

Talipova, Noila, et al. "Genetic characteristics of the course of chronic hepatitis." E3S Web of Conferences. Vol. 381. EDP Sciences, 2023.

Khasanov, B., et al. "CHRONIC HEPATITIS OF MOTHER AND MORPHOLOGICAL FEATURES OF IMMUNE SYSTEM FORMATION OF POSTERITY." The Scientific Heritage 55-2 (2020): 42-43.

Dilshod, Qayimov Mirzohid Normurotovich Khalilov Khikmatulla. "oglu.(2025). THE INFLUENCE OF THE GENERAL ENVIRONMENT ON THE DEVELOPMENT OF ALCOHOLISM [Data set]. Zenodo."

Абдухаликова, Нигора Фахриддиновна. "ГИПОКСИЕЙ ИНДУЦИРОВАННЫЙ ФАКТОР КАК МИШЕНЬ ФАРМАКОЛОГИЧЕСКОГО ВОЗДЕЙСТВИЯ." Медицинский журнал молодых ученых 15 (09) (2025): 133-140.

Ирискулов, Бахтиёр Уктамович, Нигора Фахриддиновна Абдухаликова, and Комола Толиховна Зупарова. "САХАРНЫЙ ДИАБЕТ И РОЛЬ МЕЛАТОНИНА В ЕГО РАЗВИТИИ И ЛЕЧЕНИИ." ИНФЕКЦИЯ, ИММУНИТЕТ и ФАРМАКОЛОГИЯ (1999): 93.

ABDUKHALIKOVA, NF. "IMPORTANCE OF PHOTODYNAMIC THERAPY IN PROLIFERATIVE PROCESSES." INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND PUBLIC HEALTH 6.1 (2025): 27-34. Iriskulov, B. U., R. B. Tadjibaeva, and M. B. Nosirjonova. "Differential Diagnosis of Acute Leukemia in Children." (2024).

Fakhriddinovna, Sultonova Umida, Khaydarova Gavkhar Saidakhmatovna, and Abdukhalikova Nigora Fakhriddinovna. "LANGUAGE ADAPTATION AND VALIDATION THE FPI (VOICE HANDICAP INDEX) QUESTIONNAIRE IN UZBEK IN THE DIAGNOSIS OF VOICE DISORDERS IN PARKINSON'S DISEASE." International Journal of Modern Medicine 3.10 (2024): 60-73.

Абдухаликова, Нигора Фахриддиновна, and Бахтиёр Уктамович Ирискулов. "КЛЕТОЧНЫЕ МЕХАНИЗМЫ ПАТОГЕНЕЗА МИОКАРДИАЛЬНОГО ПРЕКОНДИЦИОНИРОВАНИЯ." ИНФЕКЦИЯ, ИММУНИТЕТ и ФАРМАКОЛОГИЯ (1999): 5.

Sultanova, U. F., G. S. Khaidarova, and N. F. Abdukhalikova. "Анкетирование пациентов для оценки состояния голосообразующего аппарата, как одна из методов ранней диагностики болезни Паркинсона." Eurasian Journal of Otorhinolaryngology-Head and Neck Surgery 3 (2024): 80-84.

Abdukhalikova, Nigora F., and Bakhtiyor U. Iriskulov. "EFFECT OF PLANT PHOTOSENSITIZER PSORALEN ON MITOCHONDRIAL STRUCTURES IN INFLAMMATORY PROCESSES." Central Asian Journal of Medicine.