Articles | Open Access | https://doi.org/10.37547/ijmscr/Volume05Issue06-07

The Significance of Angiogenesis Processes and Their Target Biomarkers in Ovarian Cancer: Clinical and Prognostic Analysis

Nigora Zaripovna Babajanova , Oncogynecologist, Radiotherapist Republic Specialized Scientific-Practical Medical Center of Oncology and Radiology, Tashkent Regional Branch, Tashkent, Uzbekistan
Yashnar Salievna Mamadaliyeva , Oncogynecologist, Radiotherapist Republic Specialized Scientific-Practical Medical Center of Oncology and Radiology, Tashkent Regional Branch, Tashkent, Uzbekistan

Abstract

This article analyzes the expression of immunohistochemical markers (p53, Ki-67, VEGF, and CD34) in various histological types of ovarian cancer, along with their clinical-morphological features and prognostic significance. Marker expression levels were evaluated in relation to tumor progression, treatment effectiveness, and recurrence risk. The obtained results provide a scientific foundation for formulating individualized therapeutic strategies.

Keywords

Ovarian cancer, immunohistochemistry, p53

References

Prat J. A synopsis of the 2014 WHO classification of tumors of the female reproductive organs. Mod Pathol. 2015.

Bell D. et al. Integrated genomic analyses of ovarian carcinoma. Nature. 2011.

McCluggage WG. Morphological subtypes of ovarian carcinoma. Histopathology. 2011.

Kurman RJ, Shih IM. The origin and pathogenesis of epithelial ovarian cancer. Am J Surg Pathol. 2010.

Köbel M. et al. Differences in tumor biology between histological subtypes of ovarian cancer. Int J Gynecol Pathol. 2014.

Yemelyanova A. et al. Immunohistochemical p53 staining in ovarian cancer. Mod Pathol. 2011.

Cannistra SA. Cancer of the ovary. N Engl J Med. 2004.

Ferrara N. VEGF: basic science and clinical progress. Endocr Rev. 2004.

Hlatky L, Hahnfeldt P. Clinical implications of angiogenesis in cancer. N Engl J Med. 1996.

American Cancer Society. Ovarian Cancer Statistics. 2023.

Article Statistics

Copyright License

Download Citations

How to Cite

Nigora Zaripovna Babajanova, & Yashnar Salievna Mamadaliyeva. (2025). The Significance of Angiogenesis Processes and Their Target Biomarkers in Ovarian Cancer: Clinical and Prognostic Analysis. International Journal of Medical Sciences And Clinical Research, 5(06), 34–36. https://doi.org/10.37547/ijmscr/Volume05Issue06-07