Articles
| Open Access |
https://doi.org/10.37547/ijmscr/Volume02Issue12-03
PRE-CLINICAL STUDIES OF THE ANTITUBERCULOUS DRUG BIOMAYRIN
Abstract
By chemical modification of polygalacturonic acid with anti-TB drugs isoniazid, ethambutol and rifampicin, the macromolecular system Biomayrin was obtained. Pharmaco-toxicological studies have ascertained that Biomayrin is less toxic than low-molecular counterparts and has pronounced anti-tuberculosis activity, and with a two-fold lower dose when calculating the active substance, it has identical activity with the combined anti-tuberculosis drug Mayrin. Pharmacokinetic studies have shown that with the introduction of Biomayrin, the therapeutic concentration of the active ingredients (isoniazid, ethambutol and rifampicin) in the blood lasts longer than that of their low-molecular counterparts. It should also be noted that the chemical binding of isoniazid to the polysaccharide matrix slows down its metabolism to therapeutically inactive acetylisoniazid.
Keywords
Polygalacturonic acid, isoniazid, ethambutol, rifampicin
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