Background: Globally, preeclampsia (PE), a serious pregnancy complication, is the cause of mother and fetal morbidity and mortality. Preeclampsia and eclampsia together account for 10 to 15% of direct maternal deaths. It is distinguished by the development of proteinuria and hypertension after 20 weeks of pregnancy. In this study, the impact of platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW) on the development of preeclampsia in patients will be examined, and their relationship to the severity of the condition will be assessed. Methods: 58 pregnant women participated in a case-control study in Tashkent, with 30 age-matched normotensive controls and 28 preeclamptic (mild: n=15; severe: n=13). Results: The platelet count was lowest in patients with severe preeclampsia and considerably lower in preeclamptic patients than in controls. With a rising trend in severe preeclampsia, MPV and PDW were significantly higher in preeclampsia (p<0.001). Systolic blood pressure and MPV had a significant correlation (r=0.56, p=0.001), while PDW and hypertension had a moderate correlation (r=0.46, p=0.013). In conclusion, platelet indices—specifically MPV and PDW—have the potential to serve as indicators of preeclampsia severity. In clinical practice, their prognostic implications can aid in early risk assessment and management, thereby averting imminent eclampsia.

Preeclampsia, Platelet count, Mean platelet volume

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