International Journal of Medical Sciences And Clinical Research

International Journal of Medical Sciences And Clinical Research
ISSN: 2771-2265
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Articles | Open Access | https://doi.org/10.37547/ijmscr/Volume02Issue10-03

COMPARATIVE ASSESSMENT OF ACUTE TOXICITY OF VINCANIN HYDROCHLORIDE DERIVATIVES IN RESEARCH CONDITIONS

Yu.R. Mirzaev , Candidate Of Medical Sciences, Senior Scientific Researcher At The S.Yu. Yunusov Institute Of Plant Chemistry Of The Academy Of Sciences Of The Republic Of Uzbekistan
T.T. Khamroev , Basic Doctoral Student Of The Institute Of Plant Chemistry Named After S.Yu. Yunusov Of The Academy Of Sciences Of The Republic Of Uzbekistan
E.M. Ruzimov , Junior Scientific Researcher At The S.Y. Yunusov Institute Of Plant Chemistry Of The Academy Of Sciences Of The Republic Of Uzbekistan
B.N. Khamdamov , Basic Doctoral Student Of The Institute Of Plant Chemistry Named After S.Yu. Yunusov Of The Academy Of Sciences Of The Republic Of Uzbekistan
B.B. Abduazimov , Senior Scientific Researcher At The S.Yu. Yunusov Institute Of Plant Chemistry Of The Academy Of Sciences Of The Republic Of Uzbekistan
Sh.M. Adizov , Phd, Senior Scientific Researcher At The S.Yu. Yunusov Institute Of Plant Chemistry Of The Academy Of Sciences Of The Republic Of Uzbekistan
P.Kh. Yuldashev , Ds Doctor Of Chemical Sciences, Professor At The S.Yu. Yunusov Institute Of Plant Chemistry Of The Academy Of Sciences Of The Republic Of Uzbekistan
B.J.Elmuradov , Ds Doctor Of Chemical Sciences, Professor At The S.Yu. Yunusov Institute Of Plant Chemistry Of The Academy Of Sciences Of The Republic Of Uzbekistan
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Published Date 2022-10-18
Pages 9-15
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    19

Abstract

This research paper presents the isolation of norfluorocurarine alkaloids from the Vinca erecta plant, substances with different chemical structures and the study of toxicological properties in various types of animals. Experiments have shown that mice are more resistant to the effects of pyrazoline chloride and pyrazoline iodide than rats. From the conducted studies, it can be concluded that it is advisable to carry out the biological activity of the studied substances to rats that are relatively immune to the action of these substances and this will allow further use of dosages that are relatively harmless to humans in various pathologies.

Keywords

Acute toxicity, pyrazoline chloride, pyrazoline iodine methylate

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Yu.R. Mirzaev, T.T. Khamroev, E.M. Ruzimov, B.N. Khamdamov, B.B. Abduazimov, Sh.M. Adizov, P.Kh. Yuldashev, & B.J.Elmuradov. (2022). COMPARATIVE ASSESSMENT OF ACUTE TOXICITY OF VINCANIN HYDROCHLORIDE DERIVATIVES IN RESEARCH CONDITIONS. International Journal of Medical Sciences And Clinical Research, 2(10), 9–15. https://doi.org/10.37547/ijmscr/Volume02Issue10-03
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