The goal was to study the state of the immune system of children with laryngeal papillomatosis depending on the clinical course of the disease in the dynamics of antiviral therapy. A comparative analysis of immunological parameters was carried out in the dynamics of standard therapy (before and after), and after standard + immunotropic therapy. For this purpose, 252 children with laryngeal papillomatosis aged 3 to 9 years were examined. All children were examined and treated in the surgical department of otolaryngology of TMA. In order to determine the effectiveness of the treatment of children, the following division into groups was carried out: Group I - children with a continuously recurrent course of papillomatosis of the larynx were divided into two subgroups: Subgroup I - the comparison group received standard treatment surgery + IFN preparations (reaferon) - one course per 28 days; Subgroup I - study group surgery + IFN preparations (alpha-IFN / inosine) - according to the scheme for 1 year. Group II - children with a frequently relapsing course of PH: II a subgroup - received standard treatment surgery + IFN preparations (reaferon) - one course for 28 days; II in the subgroup - surgery + IFN preparations (alpha-IFN / inosine) - according to the scheme for 6 months. Group III - children with a rarely recurrent course of PH: III a group - surgery; III in group - surgery + likopid. Unidirectional changes in the state of the immune response in papillomatosis of the larynx were revealed, which were most pronounced in the group of children with a continuously recurrent form of papillomatosis of the larynx. In the dynamics of therapy, improvements in the indicators of cellular and humoral immunity were found;

papillomatosis of the larynx in children, interferons, interferon inducers

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