Abstract
Unsaturated fat desaturases play a pivotal role in lipid metabolism and are crucial components in the process of temperature acclimatization in various organisms. This review provides a comprehensive survey of unsaturated fat desaturases and their intricate involvement in the modulation of membrane fluidity and composition in response to temperature changes. Through an exploration of their biochemical functions and regulatory mechanisms, this paper elucidates the vital roles played by unsaturated fat desaturases in facilitating cellular adaptation to fluctuating environmental temperatures. Additionally, the review discusses the implications of these enzymes in the context of thermal stress tolerance and the evolutionary significance of their adaptive responses.
Keywords:
Unsaturated fat desaturases, Lipid metabolism, Temperature acclimatization
References
Castro, L.F.C., D.R. Tocher and O. Monroig, 2016. Long-chain polyunsaturated fatty acid biosynthesis in chordates: Insights into the evolution of Fads and Elovl gene repertoire. Progr. Lipid Res., 62: 25-40.
Schmitz, G. and J. Ecker, 2008. The opposing effects of n-3 and n-6 fatty acids. Prog. Lipids Res., 47: 147-155.
Garba, L., W. Latip, M.S.M. Ali, S.N. Oslan and R.N.Z.B.R. Abd Rahman, 2016. Unsaturated fatty acids in antarctic bacteria. Res. J. Microbiol., 11: 146-152.
Wakil, S.J., J.K. Stoops and V.C. Joshi, 1983. Fatty acid synthesis and its regulation. Ann. Rev. Biochem., 52: 537-579.
Poulos, A., 1995. Very long chain fatty acids in higher animals-a review. Lipids, 30: 1-14.
Lemieux, B., M. Miquel and C. Somerville, 1990. Mutants of Arabidopsis with alterations in seed lipid fatty acid composition. Theor. Applied Genet., 80: 234-240.
Harwood, J.L. and I.A. Guschina, 2009. The versatility of algae and their lipid metabolism. Biochimie, 91: 679-684.
Venegas-Caleron, M., F. Beaudoin, O. Sayanova and J.A. Napier, 2007. Co-transcribed genes for long chain polyunsaturated fatty acid biosynthesis in the protozoon Perkinsus marinus include a plant-like FAE1 3-ketoacyl coenzyme A synthase. J. Biol. Chem., 282: 2996-3003.
Jakobsson, A., R. Westerberg and A. Jacobsson, 2006. Fatty acid elongases in mammals: Their regulation and roles in metabolism. Prog. Lipid Res., 45: 237-249.
Parker-Barnes, J.M., T. Das, E. Bobik, A.E. Leonard and J.M. Thurmond et al., 2000. Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids. Proc. Natl. Acad. Sci., 97: 8284-8289.
Guillou, H., D. Zadravec, P.G.P. Martin and A. Jacobsson, 2010. The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice. Prog. Lipid Res., 49: 186-199.
Naganuma, T., Y. Sato, T. Sassa, Y. Ohno and A. Kihara, 2011. Biochemical characterization of the very long-chain fatty acid elongase ELOVL7. FEBS Lett., 585: 3337-3341.
